After researchers determine which protein is involved in a specific disease, they use combinatorial chemistry to find the molecule that controls the protein. High-throughput screening techniques allow scientists to use automatic fluid handlers to mix chemicals under specific test conditions at extremely high speed. Combinatorial chemistry can generate thousands of chemical compound variations in a few hours. Previously, traditional chemistry methods could have required several weeks or even months to do the same work. High-throughput screening enables automated, computerized machines to screen as many as 100,000 chemical compounds daily, seeking potential molecules as drug candidates.
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