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Technology Discussion—DNA Chips, Business and Industry Trends Analysis

Several chip platforms have been developed to facilitate molecular biology research.  For example, industry leader Affymetrix (www.affymetrix.com ) has developed chips programmed to act like living cells.  These chips can run thousands of tests in short order to help scientists determine a specific gene’s expression.

Scientists know that a mutation—or alteration—in a particular gene’s DNA often results in a certain disease.  However, it can be very difficult to develop a test to detect these mutations, because most large genes have many regions where mutations can occur.  For example, researchers believe that mutations in the genes BRCA1 and BRCA2 cause as many as 60 percent of all cases of hereditary breast and ovarian cancers.  But there is not one specific mutation responsible for all of these cases.  Researchers have already discovered over 800 different mutations in BRCA1 alone.

 


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