| A Short Biotech & Genetics Industry Glossary | i |
| Introduction | 1 |
| How to Use This Book | 3 |
| Chapter 1: Major Trends Affecting the Biotech & Genetics Industry | 7 |
| 1) The State of the Biotechnology Industry Today | 7 |
| 2) A Short History of Biotechnology | 13 |
| 3) Ethanol Production Soars, But U.S. Federal Subsidy in Question | 14 |
| 4) Major Drug Companies Bet on Partnerships With Smaller Biotech Research Firms | 17 |
| 5) From India to Singapore to China, Nations Compete Fiercely in Biotech Development | 18 |
| 6) Clinical Trials and Medical Records Processing in India Spark Concerns | 20 |
| 7) Gene Therapies and Patients’ Genetic Profiles Promise a Personalized Approach to Medicine | 20 |
| 8) Breakthrough Drugs for Cancer Treatment—Many More Will Follow | 23 |
| 9) Few New Blockbusters: Major Drug Patents Expire While Generic Sales Growth Continues | 24 |
| 10) Biotech and Orphan Drugs Pick Up the Slack as Blockbuster Mainstream Drugs Age | 26 |
| 11) Biogenerics (Follow-on Biologics) are in Limbo in the U.S. | 27 |
| 12) Breakthrough New Drug Delivery Systems Evolve | 29 |
| 13) Stem Cells—Multiple Sources Stem from New Technologies | 29 |
| 14) U.S. Government Stance on Funding for New Stem Cell Research Unclear | 31 |
| 15) Stem Cells—Therapeutic Cloning Techniques Advance | 32 |
| 16) Stem Cells—A New Era of Regenerative Medicine Takes Shape | 34 |
| 17) Nanotechnology Converges with Biotech | 35 |
| 18) Agricultural Biotechnology Scores Breakthroughs but Causes Controversy/Selective Breeding Offers a Compromise | 36 |
| 19) Focus on Vaccines | 39 |
| 20) Technology Discussion—Genomics | 40 |
| 21) Technology Discussion—Proteomics | 41 |
| 22) Technology Discussion—Microarrays | 41 |
| 23) Technology Discussion—DNA Chips | 41 |
| 24) Technology Discussion—SNPs (“Snips”) | 42 |
| 25) Technology Discussion—Combinatorial Chemistry | 42 |
| 26) Technology Discussion—Synthetic Biology | 43 |
| 27) Technology Discussion—Recombinant DNA | 43 |
| 28) Technology Discussion—Polymerase Chain Reaction (PCR) | 44 |
| Chapter 2: Biotech & Genetics Industry Statistics | 45 |
| Biotech Industry Overview | 46 |
| The U.S. Drug Discovery & Approval Process | 47 |
| U.S. FDA New Drug (NDA) and Biologic (BLA) Approvals, 2010 | 48 |
| U.S. Pharmaceutical R&D Spending Versus the Number of New Molecular Entity (NME) Approvals:1993-2009 | 49 |
| Employment in Life & Physical Science Occupations by Business Type, U.S.: May 2010 | 50 |
| Federal R&D & R&D Plant Funding for General Science & Basic Research, U.S.: Fiscal Years 2009-2011 | 51 |
| U.S. Exports & Imports of Pharmaceutical Products: 2006-1st Quarter 2011 | 52 |
| U.S. Prescription Drug Expenditures, Aggregate & Per Capita Amounts, Percent Distribution: Selected Calendar Years, 2004-2019 | 53 |
| U.S. Prescription Drug Expenditures: 1965-2019 | 55 |
| Total U.S. Biotechnology Patents Granted per Year by Patent Class: 1977-2010 | 57 |
| Research Funding for Biological Sciences, U.S. National Science Foundation: Fiscal Year 2010-2012 | 58 |
| Global Area of Biotech Crops by Country: 2010 | 59 |
| Biologics & Biotechnology R&D, PhRMA Member Companies: 2009 | 60 |
| Domestic & Foreign Pharmaceutical Sales, PhRMA Member Companies: 1975-2010 | 61 |
| Sales By Geographic Area, PhRMA Member Companies: 2009 | 62 |
| Domestic U.S. Biopharmaceutical R&D Breakdown, PhRMA Member Companies: 2009 | 63 |
| Domestic Biopharmaceutical R&D Scientific, Professional & Technical Personnel by Function, PhRMA Member Companies: 2009 | 64 |
| Domestic U.S. Biopharmaceutical R&D & R&D Abroad, PhRMA Member Companies: 1970-2010 | 65 |
| Chapter 3: Important Biotech & Genetics Industry Contacts | 67 |
| (Addresses, Phone Numbers and Internet Sites) | |
| Chapter 4: THE BIOTECH 350: | |
| Who They Are and How They Were Chosen | 107 |
| Industry List, With Codes | 108 |
| Index of Companies Within Industry Groups | 109 |
| Alphabetical Index | 118 |
| Index of U.S. Headquarters Location by State | 121 |
| Index of Non-U.S. Headquarters Location by Country | 125 |
| Index by Regions of the U.S. Where the Firms Have Locations | 126 |
| Index by Firms with International Operations | 132 |
| Individual Profiles on Each of THE BIOTECH 350 | 135 |
| Additional Indexes | |
| Index of Hot Spots for Advancement for Women/Minorities | 504 |
| Index by Subsidiaries, Brand Names and Selected Affiliations | 506 |